This policy setting determines whether Internet Explorer 11 uses 64-bit processes (for greater security) or 32-bit processes (for greater compatibility) when running in Enhanced Protected Mode on 64-bit versions of Windows.Important: Some ActiveX controls and toolbars may not be available when 64-bit processes are used.If you enable this policy setting Internet Explorer 11 will use 64-bit tab processes when running in Enhanced Protected Mode on 64-bit versions of Windows.If you disable this policy setting Internet Explorer 11 will use 32-bit tab processes when running in Enhanced Protected Mode on 64-bit versions of Windows.If you don't configure this policy setting users can turn this feature on or off using Internet Explorer settings. This feature is turned off by default.
Windows Components\Internet Explorer\Internet Control Panel\Advanced Page
Machine
At least Internet Explorer 11.0
HKLM\Software\Policies\Microsoft\Internet Explorer\Main!Isolation64Bit
inetres.admx